PKRRATING - AN OVERVIEW

3B). R526 from the loop in between αJ and αI anchors the C-terminal portion of the activation loop by forming a salt bridge with E458 at the base of αEF. Q459 stabilizes the HRD motif by a hydrogen bond to the key chain carbonyl of R413. The idea on the activation section is stabilized by a hydrogen bond involving Y454 and E480 from αF. from th